All eyes will be on Emirates Stadium on Sunday when Tottenham chase a first league double over Arsenal in the north London derby since 1992-93.
Premier League leaders Manchester City are also in the capital, giving struggling Fulham a tough task at Craven Cottage in Saturday’s late kick-off.
The most intriguing tactical battle of the weekend could come at Elland Road, where Marcelo Bielsa’s Leeds United host Thomas Tuchel’s Chelsea, while West Ham are likely to face a thorough examination of their top-four ambitions at Manchester United.
Here, we give a few pointers on which players could come up trumps in fantasy football terms.
England goalkeeper Henderson has not played too frequently since opting to make a go of things with parent club Manchester United.
But when he has featured for Ole Gunnar Solskjaer’s side, the 24-year-old has generally impressed, even if his midweek outing against Milan in the Europa League contained an unwanted sting in the tail.
If David de Gea is absent once more against West Ham, Henderson’s 19 saves from 22 shots faced in the Premier League this season suggests the United goal is in safe hands. His save percentage of 86.4 is the best of any goalkeeper to have played more than one game this season.
Given the dearth of natural left-back options available to England manager Gareth Southgate, a strong season at West Ham for Cresswell could turn out to have been perfectly timed.
The full-back is also a threat in opposition territory, with his seven assists more than any other defender in the division. It is a left-back dominated list, with Lucas Digne up next on six from Andy Robertson, Luke Shaw (both five) and Southgate’s first choice Ben Chilwell (four).
Seven assists also matches the most productive season of Cresswell’s career in that regard, having provided the same number in 2017-18.
Tuchel has overseen a defensive transformation since taking over from Frank Lampard, tightening up an unhelpfully leaky backline.
Club captain Azpilicueta has been a pillar of this turnaround. His eight clean sheets are the most for any Premier League defender in 2021.
Azpilicueta is one ahead of rejuvenated club-mate Antonio Rudiger, while Manchester City centre-backs John Stones and Ruben Dias and Manchester United duo Harry Maguire and Aaron Wan-Bissaka similarly have seven apiece.
Relegation-haunted West Brom would be forgiven for dreading the sight of Crystal Palace winger Zaha.
In his past four outings against the Baggies, the Ivory Coast international has scored four times.
That run includes a second-half brace from when Palace hammered the Baggies 5-1 at The Hawthorns in December – a result that would prove influential in Slaven Bilic’s sacking later that month.
England forward Sterling sat out City’s 5-2 win over Southampton in midweek after his latest disappointment in the derby against United.
His native London is a far happier hunting ground, with the 26-year-old amassing 16 goal involvements (10 goals and six assists) in his previous 16 Premier League starts in the English capital.
Sterling continued that streak last time out at Emirates Stadium, heading the only goal early on in a 1-0 win over Arsenal.
This weekend, another wide forward on a hot streak will be foremost in Arsenal’s thoughts.
A revitalised Bale scored twice in a 4-1 win over Palace last weekend, meaning he has had a hand in six goals in his past four top-flight appearances (four goals and two assists).
And, if you believe the form book stays on this side of the window on derby day, the Wales star has five Premier League goals against Arsenal – more than against any other side in his career.
As the battle for a top-four finish hots up, sides in the chasing pack will need players to weigh in with ‘heavy’ goals.
Thankfully for Everton, no player’s goals in the Premier League this season have been worth more in terms of points gained than Calvert-Lewin’s.
The centre-forward, who was rewarded with an England breakthrough following a sensational start to the campaign, has netted 13 times in the league this season – strikes that have won a total of 14 points.
Burnley, this weekend’s visitors to Goodison Park, could be the next team to add to his tally.