Valencia sacked Javi Gracia as a coach.
His dismissal follows a 3-2 loss to Barcelona which made him six games without a win in La Liga.
Valencia took the lead in Sunday’s game thanks to Gabriel Paulista, only for a Lionel Messi sandwiched by Antoine Griezmann’s effort to put Barca in charge before Carlos Soler responds.
They will likely avoid the fall but still have work to do as Valencia are just six points ahead of the relegation zone with four games to go.
Voro will return for a third term as interim boss, having also been in charge of goalkeeper three times and held the position permanently once in 2016-2017.
Gracia, who was only appointed last July, had a 23.53 league winning percentage, the lowest for a permanent Valencia coach since Cesare Prandelli stepped down after eight La Liga games in 2016 with a only victory to his credit (12.5%).
Valencia host Real Valladolid in a key bottom-of-the-table game at Mestalla on Sunday.